- For the short-term relief of mild to moderate pain
Details:
- Manufacturer:
- The drug is manufactured by Hikma Pharmaceuticals USA Inc. and distributed by West-Ward, Inc.
- Strength:
- 10mg/mL of acetaminophen and 3 mg/mL of ibuprofen
- Form:
- Supplied as a clear, colorless solution for intravenous injection in a 100mL single-dose vial
- Application:
- It is an analgesic combination for the short-term relief of mild to moderate pain
- As an adjunct to opioid analgesics for moderate to severe pain in adults
Mechanism of Action:
- Is a combination drug, so its mechanism of action is based on the synergistic effects of its two active ingredients, acetaminophen and ibuprofen
- The combination provides enhanced pain relief by targeting different pain pathways
- Acetaminophen:
- While its exact mechanism is not fully established, acetaminophen is primarily thought to produce its analgesic and antipyretic effects through central actions
- Ibuprofen:
- Classic NSAID that works by inhibiting the cyclooxygenase (COX) enzymes both centrally and peripherally
- When combined, as in Combogesic IV, the different mechanisms of the two drugs lead to a stronger, more comprehensive effect on pain
- This combined approach, known as multimodal analgesia, provides superior pain relief compared to using either drug alone, as it acts on multiple pathways at once
